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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '50c3a616786e3404bdb2c3b00c5112b2a4f7df5393727b5a510416245db4867c' 
  AND token = 'U67PXaAGAlS3FplMQH8cNlfyDONGNPXhW1yaCS3BEA4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}