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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '8259222c8aa69bdea526f85bfd5853482e1435ed51d7fffc9f012608d0f406c1' 
  AND token = 'minRis1j5I/spsyzv+KoepA80PRNSd3BmfKLQ8WvV3c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}