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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '12e7bb9aac6121d0a35f2e76dce9e79fa2a719009112711f300c81a1bfb55f52' 
  AND token = 'FIPR9IQAxoxLpjcdRh1k+JCTaVbPwSeASXH2bcCgAFA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}