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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '168eb6290d1a8b491f8bcb1c37541911c72b3ef12bfcff9f013b1b89c116f335' 
  AND token = 'fix4o12kDDXmY2juuuoG8hXi2pTEOB6uAb4Slihf0h4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}