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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '00e0279498b48a660c6556664dd181021df3da5366f9f1cedaff1f41d506c443' 
  AND token = 'qIRZKpTOMQX7oIkFxRStJn6TtZHVtGLIjjaSCrS2zZE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}