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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '85a3f4a36daee2115fe6df6026cb5ea243aece3a9700ff17fcca266d981170c1' 
  AND token = 'OA9QU3IMDrpmNdJEJ1KiBe3c+vGeVNvipaF/SVYmKBU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}