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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '78149a1b38171aaf06f49045efe4873eecfc2fa99e02e7094589c128bfd2d021' 
  AND token = 'wcuxk8GN2iUODEAm5HwS/wZmKvnikR1XejcwBriCl5U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}