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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'aedf44d415100ba5b9d0a65cfeabff26d81eacfe171b407bfae7c8e390c3f597' 
  AND token = 'BX+10Lg+prjT2CfZXZUb6RR71RrsUTAoLUV7Q0uFH+U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}