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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '721f6014d90219b167815b444244cfedb798e001f16d8d71b16413c45ec6c132' 
  AND token = 'iCQEzLAOZ0JY2v1D0/k9vO650PSPNxW/+TsOOGGCPfo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}