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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '450ec3521e6ea67861cbe20016256fcb30d0a6dba5d811c15d53169308211b8a' 
  AND token = '51aShb+cXBzT95bDaRmqfsl6oseirqUVb3873xfhwS8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}