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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '53c01ec87e5ecd5f8ce2c8def71cf906c4816b1a861dd9c2fe545e1306201124' 
  AND token = '9CyFtBXw+yHpBnNm0f8CNsMUxpMt/zhfGjmwFtM7rBM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}