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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '581cf7ee52196a6b73f65c358dd97d2200a2c1271b8b1149e9e8d77b748ca817' 
  AND token = 's6it2oE/NgcXgGRE4Tie8OypfpRLJeywjBqo3rBCbd0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}