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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '643f50dc2dac058bb2dc4b3d2c4b54d011a55cf503052004e7c8687011369a68' 
  AND token = '/i9IkupJO/wTFuZZEx9CcFA9UiMlpa5gv4xdTPT56WY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}