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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'edc6069902bab8245e8b886739e53a70a856a5ca86b0ffcd2d91f69879a2f829' 
  AND token = 'E7Bk81aqAjVZwR+xtKMSk+zMb7mC5iHYZCwaocQr80Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}