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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '2b0e0e5ee837315e07c68df347855f907e41d62e83896775f95ed2e5af193574' 
  AND token = '7XE/K7C8K2/PIaruhAtEM4clOWkuyiG9LWMm6T1jr78=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}