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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '750115e341fe029a5ec026272e1f627ed0d407d2214e102f14ce10356b5690b5' 
  AND token = 'C23JPz3cyTmpmi23ORqjELMyZmh2WqiCcqY49bIhacE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}