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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '737affe0f9a979a91883e553a88f030e33a96e757fa30c0a91864fb5ad4afca5' 
  AND token = 'W/WBrrPdWtb3sdG7REEia+6mSrojp7+Med6oN2JkUPI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}