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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '78831914fc03dce297aa4c33096f67f8e69aff18e2a0785257a9b80274250422' 
  AND token = 'vNGm7U7tit4yMEAsPwEICFNUjWr6G6hanL0tTEadQWw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}