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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '12226d5d47a346945fb086e61fcdf76dbd0c4e924f362c9efe1cf008c13372f0' 
  AND token = 'KOy7Y5uO0l2cyvyEm3V09gCEu7IKZyBiA7m2YbiBGc0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}