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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '1a253b8774ff21167909277a6225430d2e13a0f3b173149dd4f92e2db8fbe721' 
  AND token = 'THXTO46RIkdlDYCcnEXHmPPEF938E0GP1jdFrfXHBJc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}