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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '181d7aca7016ecd0830f43aa7c033ed9e6d2a9477bc0ee1d7c129806b5535550' 
  AND token = 'HCrH6BnTImEWMP0oitLX0XJLbBlqqswqIv3019/RnBA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}