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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'f680f77d8fb00161de0ee439809a86f85a2e9b852195a5a51c396e8cdb3b5f39' 
  AND token = '2+F11eXWdTR19iDA2Aubg25Px1acFetzIZfu6UZlBLE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}