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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '65ec7092c1ce5d1efb2d9760fd11067ff107171f5dd4f169dee5c166bac01a04' 
  AND token = 'H3y5hWTWhvE5zS+Gi64kgwFvPg8vJlxfel6WHiSX7jc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}