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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '2180e986a20159ba6f490a2ce0eaf67aca1653ca5e732da371e2a780af059fe5' 
  AND token = 'iZONbjsN8GCcUmSOFI8LYlwd1/HUkTo7i4VlRwqRec0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}