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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '49060e472498986647ef5ded9ae60e14eb40d8df9fa2a663c559fbe65ec41d7b' 
  AND token = 'SZYR4/vdAudtaBnKBy8pDlaG2g6h6x9Rxbx7MyGOGEc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}