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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '9d4a487d718ca2da137381237affc1e6b49aef5494ca20ec850b01f173c5c169' 
  AND token = 'eIpDyDn5Q3ciidkcSmURHARKeoAWLn/ka9ZeV7Y36Zo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}