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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '2580f9884e82048a96556e7fecb9134d0be19714f1c12ffb0a0d7534ed8daf44' 
  AND token = 'guM5DxcKey9N8peND4B+8sP0xcBob4LZjD1B8576Zco=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}