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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '2535f1d2d36413d9e639de75fc714908faf7f1f5fa7e7855380b6c3a16e3f650' 
  AND token = 'HEwOkHz222M0vlvYr5XlXrtmDv4CL5xUEY2fNsvhEsg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}