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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '16863423a88141e77898101a986729b46bfade88ee8456ec03ee634ed27c3bb3' 
  AND token = 'E7xR1SIkyCjlDzimOtXjxnUgbSII9htxprat/pHt3Ek=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}