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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '04a0ffbd1291519945db847db2171262c3e75bddf6f34fb346ce1d12bd3585ba' 
  AND token = 'zfkVa/I/vRTCaMZtKmYKO6tyUvVatbR2PTn0MR7fpmM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}