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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '53e225b0c705482702e3351376fd2a21e73e457b3d2559833e498a55eecda0a5' 
  AND token = 'G0y1Y7Wt5LKrt2xJ3MiPgPMzQlLWhCOEHqn5cIPIbn0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}