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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '25266d7fe08fca7fbc8be6e0d4543005f4b0fea657fcdc801cce13644f67f0ff' 
  AND token = 'AFCtgqh+iDq36EAlWHe1IsYuYI9nysQ97Sh1qCuUStQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}