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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '59226b6b68b20c329e3cf3be654ecfde4aaf0611ee2e8103a98c5b32baf4b99f' 
  AND token = 'UGuuQH9zDlo8sJ6jvT6pTUQ+DYj/REp7rxHezEkeDtU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}