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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '450bb77b63c60dbcc7b3316a18defee2f0e24ca4c7c8d658b4a65acc5829b634' 
  AND token = 'XTha24L4ox/IXNxVJ2h6QRIoozHv6EJAuTdnE6MDT/4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}