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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'eac089e7a5856952579bb58159b67fb9b8711008afda4107dd3217aa64996af0' 
  AND token = 'UpSx4L9K8n3jTtkDg9gvwoS5faA6g0vvTzDeMgxF6OE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}