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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '4da5a5ea79a98b108ebd9bcbb5c4be40909e787e556a078b9f34741d3753f933' 
  AND token = 'pTHrNF7vcuR+hIxxIPOvZeNa0Hs2qMZEBDbbIYKPQIA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}