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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '80b2284b45dc066a11f79e48222d4597a7330d22590ad65c9f50acdf4f090825' 
  AND token = '2ef7yfMM/F3+Uv4fMWysriv9a6NVXQd0xaXHwZz9jQY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}