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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'e65befc048838f45e9454d05948127fd3a5018dd407f159b3115e36d03ad28b5' 
  AND token = '+IRwkayUFygCU/k0xBXpOYRDlcZlDeQrearsUi9ddSA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}