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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '781d3a259d7a1c08fec0a8303e4f4d8767bbc66d19222b67a3fc7fe2c5717234' 
  AND token = '4p2zIk5eHzbyTBkYmnFXFe0msIlSYA16qWCao+cKnDk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}