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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '3580f44024e4c88608472ebc0b432dba351680606c898d6be14e91184cca7bc6' 
  AND token = 'VDSmn/f1wBZUAwPdsMyLIsXY1aFQoNRw9AzU5yrJ4XU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}