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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '854cd3efa9f95fe9b690566a9b1f3261e7e267ce73bf11fa388425357ee1fb87' 
  AND token = 'VVWIlML455fesrTxsAZ0AHtZNuMFaZu+TSj6b27l7s4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}