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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '25104ef9b52f20a648d08a5d5ed793d53afd9c86043d3efee862a298c0a06ca1' 
  AND token = 'P1UudPCvpJOixMt0ZGwcvw8jfckYz9MuMZMiUh+Sf5g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}