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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '1443aeb081b2f25e8b3c3d0e9797355c4d2a408dfeee989d11f7b12a827ff9cb' 
  AND token = '0+KC0eUqizbIt28SmjVMzlLz12cgPH21fMRo7fM3FC4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}