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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '53dd45bb626bb536bd534391caa2b01c954ea31c0332298fe31deaf17c9f4c43' 
  AND token = 'ANcPScnBI3xlmQNx+inoSc04yn358lWQg61niDCttWU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}