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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'd8d66a156cb1e874b7e0f48ab018def014ceaa2589b2e9e85b2749876f9c4789' 
  AND token = 'zhA32SLVsvG2xai9L90Hs/qcEdkYlD37zIIDeC3ro4k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}