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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'ec6af17aa05751cf9e470fdb1afe807a85429b062895a3d73fcd2fe4c3e48f66' 
  AND token = '+Uf+nE+DaCiP2Qr1WPHGW7aKNCSXFIXfLT74KwP27N8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}