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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = '2589574566a57acd76f0bfe385f9a747820ff6c7661c8d196c7f734456a508ca' 
  AND token = 'Y7Zf3fGpmJDbfp/tOClqgOnexI3VpNxFNclIqIUHxNI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}