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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'afc408bf420a89f682533871ca50a888fd54e58bd8da5a974cf3023e5dc2e485' 
  AND token = '648JbIBTnJvhh9keNl5SLD2CdtJkrohZmfcnPAT68WQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}