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SELECT 
  1 
FROM 
  cscart_aprilec_print_temp_designs 
WHERE 
  session_id = '5S1X-TC3Y-TWWP-U1T1-L8P9-2DVV-WBX3-FNSM' 
  AND product_id = 280 
  AND expires_at > 1777640857 
  AND confirmed = 'Y' 
LIMIT 
  1

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}