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SELECT 
  1 
FROM 
  cscart_aprillock_keys 
WHERE 
  key_id = 'c00a8219624c16f6c4f507df72307e9d2003ce69f8142393259937e085429b10' 
  AND token = 'OAdzT46MxdiG/GRn2UI9cNVqeCIJKBEooDw1HxNDIfM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}